Endocrine Abstracts

Background: Acromegaly is a rare Endocrine condition caused by excessive secretion of growth hormone; in 2022, there were approximately 3500 people with a known diagnosis in the UK. Patients with Acromegaly can achieve successful remission of the disease with medical therapy, pituitary surgery and radiotherapy (sometimes a single treatment, sometimes combination). However, these treatment options have associated risks, including side effects, late effects of r...

Introduction: In 2003, the UK National Institute for Clinical Excellence (NICE) established guidelines on the use of GH in adults. These guidelines state that recombinant GH should be used only for adults with a severe GH deficiency that severely affects their quality of life. To assess current practice in relation to these guidelines, a review of patients receiving GH treatment was performed. The aims were to assess if adults with GH deficiency met NICE criteria for GH therap...

Section 1: Case history : The case concerns a 53-year-old gentleman who developed calciphylaxis following a bioprosthetic aortic valve replacement. His past medical history included Multiple Endocrine Neoplasia Type 1 (MEN-1) for which he had previously undergone total parathyroidectomy with failed graft auto-transplantation. The resulting hypoparathyroidism was managed with alfacalcidol and calcium supplements. Post cardiac valve replacement he developed acute renal injury an...